University Chemistry ›› 2015, Vol. 30 ›› Issue (5): 1-6.doi: 10.3866/pku.DXHX20150501

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The Brief Introduction to Chemical Genetics

Gao Lei2,3, Lei Xiaoguang1,2,3   

  1. 1. Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China;
    2. Graduate School of Peking Union Medical College, Beijing 100730, China;
    3. National Institute of Biological Sciences, Beijing (NIBS), Beijing 102206, China
  • Published:2015-10-24

Abstract:

Chemical genetics, a new interdiscipline emerging at the nineties of the 20th century, is an approach for studying biological systems by using bioactive small molecules which can interact with their target proteins, and is complement of classic genetics approaches in term of methodology. The history of chemical genetics can be dated back to a few centuries ago and it still plays important role in the target identification of drug discovery.

Key words: Chemical genetics, Classic genetics, Bioactive molecules, Target protein